Thalamofrontal synaptic weakening underlies short-term memory deficits from adolescent NMDAR hypofunction
Jinseon Yu, In Sun Choi, Gyu Hyun Kim, Sang-Kyu Bahn, Jin‐Mo Kim, Sungwon Bae, Taekwan Lee, Joon Ho Choi, Jun Soo Kwon, Minah Kim, Ji-Woong Choi, Kea Joo Lee, Jong‐Cheol Rah
This study shows that adolescent NMDAR hypofunction impairs short-term memory by weakening thalamofrontal synapses, not through interneuron dysfunction.
Science Advances · Sep 23, 2026Peer-reviewedNeuroscience