Mingbo Cheng

This study identifies polyploid cardiomyocytes as disease-specific transcriptional states in the mammalian heart and suggests targeting them for heart failure treatment.

This study investigates the postnatal maturation of the small intestinal epithelium, identifying developmental regulators as key drivers over microbiota effects.

PHLOWER infers complex differentiation trees from multi-modal single-cell data using Hodge Laplacian decomposition, showing effectiveness in kidney organoid data.

PILOT uses optimal transport to analyze single-cell and pathomics data, detecting disease-associated samples and non-linear changes in cell populations and tissue structures.

This study generates a high-resolution spatial multi-omic map of human myocardial infarction by integrating single-cell gene expression, chromatin accessibility, and spatial transcriptomic data to reveal cellular zones of injury, repair, and remodeling.

MOJITOO integrates multimodal single cell data using canonical correlation analysis, outperforming existing methods in computational efficiency and clustering.

scOpen improves downstream analysis of sparse scATAC-seq data by imputing open chromatin regions, revealing regulatory changes in kidney fibrosis.