Lei Sun

Ferroptosis is executed through caspase-5 cleavage of gasdermin E in ovarian cancer cells

This study identifies caspase-5 cleavage of gasdermin E as the mechanism by which ferroptosis is executed in ovarian cancer cells.

Assessing and Optimizing Low-Frequency Somatic Mutation Detection: A Multi-Platform High-Throughput Sequencing Perspective

This study evaluates and improves low-frequency somatic mutation detection across multiple sequencing platforms using a simulated benchmark and a machine learning-based caller.

CMS: Achieving Uniform and High-Quality Sequencing across Challenging Non-canonical Genomic Regions

CMS improves sequencing uniformity and accuracy in non-canonical genomic regions by optimizing chemistry and enzymatic systems, reducing low-coverage bins and false negatives.

Protein inverse folding through joint modeling of surface and backbone geometry

This paper introduces Surleton, a framework for inverse protein folding that jointly models backbone and surface geometry, improving sequence recovery and predictive confidence on benchmark datasets.

HDAC11 Regulates RNA Splicing via De-Fatty Acylation of SF3B2

This paper shows HDAC11 de-fatty acylates SF3B2 at K10, altering its pre-mRNA binding and promoting AR-v7 splicing in HCC cells, but not in prostate cancer cells.

Therapeutic interleukin-2 rewires skeletal-immune circuits to reverse postmenopausal bone loss

This study shows that low-dose IL-2 therapy reverses postmenopausal bone loss by modulating immune cells and osteoclast activity in mice.

Graft protection by myeloid progenitor cells using lethal or non-lethal preconditioning.

This study shows that closely matched myeloid progenitor cells can protect skin and trachea grafts without lethal preconditioning or HSC transplantation.

Improved characterization of gene-environment interactions for vitamin D through variance quantitative trait loci

The paper identifies variance quantitative trait loci (vQTLs) for vitamin D levels and characterizes gene-environment interactions involving modifiable factors and sex.

Detecting latent gene-environment interaction when analyzing binary traits

This paper introduces a method to indirectly test gene-environment interactions for binary traits by leveraging non-additive genetic effects and applies it to the UK Biobank dataset.

Ribo-macs derived from nucleoli:big ribosome clusters in the cytoplasm of naive stem cells

The paper identifies and characterizes Ribo-macs, large ribosome clusters in naive stem cells, showing their dynamic nature and role in protein synthesis related to organelle biogenesis.

In vivo structural characterization of the whole SARS-CoV-2 RNA genome identifies host cell target proteins vulnerable to re-purposed drugs

The paper maps the in vivo structure of SARS-CoV-2 RNA, identifies novel structural features, and predicts host proteins interacting with the RNA using deep learning.

HDAC11 Suppresses the Thermogenic Program of Adipose Tissue via BRD2

This study shows that HDAC11 suppresses thermogenic programs in adipose tissue via BRD2, leading to improved metabolic outcomes in HDAC11-deficient mice.

HDAC11 Deficiency Prevents High-Fat Diet-Induced Obesity and Metabolic Syndrome

This study identifies HDAC11 as a key regulator of metabolism and obesity, showing that its deficiency prevents high-fat diet-induced obesity and metabolic syndrome in mice.