Philipp E. Scherer

This study identifies seipin and perilipin 3 as distinct regulators of early lipid droplet biogenesis by promoting nucleation and stabilizing nascent droplets, respectively.

This study investigates the role of UPP1 in β-cell function and shows that UPP1 deficiency impairs uridine-potentiated GSIS and MAPK activation in mice and humans.

This study identifies perineurial cells as integrators of leptin and sympathetic outflow, showing their role in obesity protection through barrier function and beta 2 adrenergic receptor regulation.

The paper identifies complement deactivation as an immunometabolic checkpoint reduced by calorie restriction, which lowers inflammaging in humans and mice.

This study shows that reduced hepatic pyrimidine synthesis during fasting and obesity promotes insulin resistance and obesity by increasing hepatic glucose production and decreasing insulin clearance.

This study develops an ETP-specific knockout mouse model to demonstrate ETP's critical role in kidney fibrosis during ischemia-reperfusion injury.

This study identifies Adig as a regulator of lipid droplet formation by stabilizing the dodecameric seipin complex, leading to increased fat mass and thermogenesis in mice.

This paper investigates 4-Methylumbelliferone's potential as a repurposed treatment for liver fibrosis, finding that it lacks efficacy at translatable doses and has an unclear mechanism.

This study compares adiponectin-deficient mice to show that intracellular globular adiponectin regulates adipose tissue metabolism by modulating PPARγ activity.

This study shows that loss of CnAβ1 enhances brown adipocyte differentiation and metabolic activity through FoxO1 activation, leading to improved insulin sensitivity and reduced body weight on a high-fat diet.

The paper introduces ATAT, an ImageJ plugin for automated analysis of adipocyte size and extracellular matrix in white adipose tissue histological sections.

This study shows that Arid1a loss enhances pancreatic β-cell regeneration by activating EGF signaling, protecting against diabetes.

This study identifies circular RNAs encoded by human polyomaviruses that produce proteins and may contribute to viral pathogenesis.

This study shows that HDAC11 suppresses thermogenic programs in adipose tissue via BRD2, leading to improved metabolic outcomes in HDAC11-deficient mice.