Sheila Collins

This study identifies a novel crosstalk mechanism between cardiomyocytes and adipocytes in obesity-associated HFpEF driven by natriuretic peptide-mediated inhibition of Wnt5a release from adipocytes.

This study shows that inhibiting salt-inducible kinases (SIKs) reduces weight gain and improves diastolic heart function in obese mice with heart failure with preserved ejection fraction (HFpEF).

This study identifies PPARγ as a regulator of Nprc gene expression in adipocytes through long-range enhancers, linking it to diet-induced changes in adipose tissue.

This study shows that HDAC11 suppresses thermogenic programs in adipose tissue via BRD2, leading to improved metabolic outcomes in HDAC11-deficient mice.