Martin Chalfie

Synaptic and neural pathway redundancy enables the robustness of a sensory-motor reflex and promotes predation escape in C. elegans

The paper identifies genetic redundancy in the touch response circuit of C. elegans, showing how it contributes to the robustness of sensory-motor reflexes and enhances escape behaviors.

Opposing effects of an F-box protein and the HSP90 chaperone network on microtubule stability and neurite growth in Caenorhabditis elegans

The paper shows that Hsp90 chaperones and the F-box protein MEC-15 have opposing roles in neuronal differentiation, with Hsp90 inhibiting neurite growth and synaptic development in C. elegans.

Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans

The paper shows that ZAG-1 inhibits EGL-44/EGL-46 to promote TRN differentiation in C. elegans, forming a negative feedback loop that regulates neuronal fate choice.

GEFs and Rac GTPases control directional specificity of neurite extension along the anterior-posterior axis

The paper identifies GEFs and Rac GTPases that specify directional neurite extension along the anterior-posterior axis in C. elegans neurons.