Sandeep Kumar

Adaptive co-transmission shapes sensory encoding and behavior

The paper shows that coexisting neurotransmitters in C. elegans are differentially regulated by experience and contribute distinctively to behavior.

Distributed control circuits across a brain-and-cord connectome

The paper presents the first densely reconstructed adult fruit fly connectome integrating the brain and ventral nerve cord, revealing distributed control circuits involving local and long-range neural connections.

Experience-Dependent Gain Modulation Drives Thermosensory Responses in Behavior

The paper shows how thermosensory neurons in C. elegans use gain modulation based on experience to encode temperature changes relevant for navigation.

Synaptic and neural pathway redundancy enables the robustness of a sensory-motor reflex and promotes predation escape in C. elegans

The paper identifies genetic redundancy in the touch response circuit of C. elegans, showing how it contributes to the robustness of sensory-motor reflexes and enhances escape behaviors.

Decoding sexual dimorphism of the sex-shared nervous system at single-neuron resolution

The paper profiles single-cell RNA sequencing data from sex-shared neurons in C. elegans to reveal molecular dimorphism and sex-biased gene expression patterns.

Functional Interrogation of Neuronal Subtypes via Intersectional Expression of Optogenetic Actuator Reveals Non-linear Components in a Linear Circuit

The paper uses a split GAL4-based genetic AND gate to optogenetically interrogate specific touch receptor neuron subtypes in C. elegans, revealing non-linear components in a seemingly linear neural circuit.

Hierarchical behavior control by a single class of interneurons

This study identifies a dual role for SAA interneurons in C. elegans, influencing both short-term rhythmic motor activity and long-term behavioral transitions.

An inhibitory acetylcholine receptor gates context dependent mechanosensory processing in C. elegans

The paper identifies an inhibitory acetylcholine receptor in C. elegans that gates context-dependent mechanosensory processing during turning behavior.

Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior

The paper shows that blocking programmed cell death in C. elegans leads to extra neurons that alter specific behaviors like reversal frequency and duration.

TWISP: A Transgenic Worm for Interrogating Signal Propagation in C. elegans

The paper introduces TWISP, a transgenic C. elegans strain that enables optical measurements of signal propagation at brain scale and cellular resolution.

FlyWire: Online community for whole-brain connectomics

FlyWire enables collaborative proofreading of whole-brain connectomes through an online platform, demonstrating its utility in reconstructing and analyzing mechanosensory neuron circuits.

The G-protein coupled receptor SRX-97 is required for concentration dependent sensing of Benzaldehyde in Caenorhabditis elegans

The paper identifies SRX-97 as a GPCR in C. elegans that mediates high-concentration benzaldehyde sensing in ASH neurons.