Author

Amber R. Hackett

Washington University in St. LouisORCID 0000-0002-9097-1534Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

A. Joseph BloomiD· 2 shared Aaron DiAntonioiD· 2 shared Amy M. StricklandiD· 2 shared Jeffrey MilbrandtiD· 2 shared Yo SasakiiD· 2 shared Yurie YamadaiD· 2 shared Joseph E. IppolitoiD· 1 shared Robert E. SchmidtiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

A. Joseph BloomORCID

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2 papers

Recent·Most cited

NeurosciencePLoS ONEPeer-reviewedApr 17, 2026

Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline

Shweta Tendulkar, Tong Wu, Amy M. Strickland…·Aaron DiAntonio

The paper investigates how partial disruption of lactate metabolism, specifically through LDHB loss, synergizes with ALS genetic risk factors to accelerate motor decline.

2 citationstop 5%

mousestatistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 29, 2022

Disruption of lactate metabolism in the peripheral nervous system leads to motor-selective deficits

A. Joseph Bloom, Amber R. Hackett, Amy M. Strickland…·Jeffrey Milbrandt

This study shows that disrupting lactate metabolism in Schwann cells or motor neurons causes motor axon degeneration, while sensory axons remain unaffected, highlighting a specific dependency of motor axons on lactate shuttling.

8 citations

mouseexperimental assay

𝕏 PostBluesky