Author

Xin‐Yun Lu

Augusta UniversityORCID 0000-0002-9103-4542Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Yun LeiiD· 4 shared Quansheng DuiD· 3 shared Neal L. WeintraubiD· 2 shared Yuting CheniD· 2 shared Alvin V. TerryiD· 1 shared Amin Karimi Moghaddam· 1 shared Anilkumar PillaiiD· 1 shared Ashutosh TripathiiD· 1 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersNeuroscience

Yun LeiORCID

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Author profile →

4 papers

Recent·Most cited

Atypical Chemokine Receptor DARC/ACKR1 Is Expressed Selectively by Neurons with Regional Heterogeneity and Protects against Neuroinflammation and Cognitive Impairment

V. N. Sankeerth Kanumuri, Ming Guo, Jayvon Nougaisse, Xujun Ma, Quansheng Du, Neal L. Weintraub, Yun Lei, Xin‐Yun Lu

This study identifies DARC/ACKR1 as a neuron-specific receptor that reduces neuroinflammation and cognitive impairment in mice and humans.

bioRxiv · Sep 14, 2026 · PreprintNeuroscience

Neuronal HDAC9: A key regulator of cognitive and synaptic aging, rescuing Alzheimer's disease-related phenotypes

Yun Lei, Yuting Chen, Ming‐Lei Guo, Florikaben Patel, Yu Bai, Brandee M. S. S. Goo, Quansheng Du, Neal L. Weintraub, Xin‐Yun Lu

This study identifies HDAC9 as a critical regulator of cognitive and synaptic aging, showing its protective role in Alzheimer's disease.

Molecular Psychiatry · Apr 4, 2026Peer-reviewedNeuroscience

Activation of DMH GABAergic neurons, but not local GABAergic AgRP neurons, attenuates chronic stress-induced POMC neuron hyperactivity

YuTing Chen, Amin Karimi Moghaddam, Quansheng Du, Yun Lei, Xin‐Yun Lu

bioRxiv · Apr 3, 2026 · PreprintNeuroscience

Cholinergic forebrain activation improves cognition, boosts neurotrophin receptors, and lowers Aβ42 levels in the cerebral cortex of 5xFAD mice.

Jacob Kumro, Ashutosh Tripathi, Yun Lei, Jeremy Sword, Patrick M. Callahan, Alvin V. Terry, Xin‐Yun Lu, Sergei A. Kirov, Anilkumar Pillai, David T. Blake

This study shows that stimulating cholinergic pathways in 5xFAD mice improves cognition, increases neurotrophin receptors, and reduces Aβ42 levels in the cerebral cortex.

Cerebral Cortex · Feb 15, 2023Peer-reviewedNeuroscience