Author

Emily V. Dutrow

National Institutes of HealthORCID 0000-0002-9113-8528Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Acadia A. KocheriD· 3 shared James P. NoonaniD· 3 shared Severin UebbingiD· 3 shared Timothy NottoliiD· 3 shared Deena EmeraiD· 2 shared Kristina Yim· 2 shared Angeliki LouviiD· 1 shared Daniel B. BurkhardtiD· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenetics

Acadia A. KocherORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CpG island turnover events predict evolutionary changes in enhancer activity

Acadia A. Kocher, Emily V. Dutrow, Severin Uebbing, Kristina Yim, María F. Rosales Larios, Marybeth Baumgartner, Timothy Nottoli, James P. Noonan

The paper shows that turnover of CpG islands in enhancers is linked to changes in enhancer activity across mammals, including humans, and contributes to gene regulatory innovation.

Genome biology · Jun 13, 2024Peer-reviewedGenetics

Domestic dog lineages reveal genetic drivers of behavioral diversification

Emily V. Dutrow, James A. Serpell, Elaine A. Ostrander

The paper identifies ten major canine genetic lineages and their behavioral correlates, showing breed diversification is driven by non-coding regulatory variation.

Cell · Dec 1, 2022Peer-reviewedGenomics

Modeling uniquely human gene regulatory function in humanized mice

Emily V. Dutrow, Deena Emera, Kristina Yim, Severin Uebbing, Acadia A. Kocher, Martina Krenzer, Timothy Nottoli, Daniel B. Burkhardt, Smita Krishnaswamy, Angeliki Louvi, James P. Noonan

The paper examines the role of the human-specific enhancer HACNS1 in human evolution by analyzing its effects on gene expression in humanized mice.

Nature Communications · Jan 13, 2022Peer-reviewedGenomics

Disrupting Pitx1 Regulatory Topology Results In Overtly Normal Limb Development

Richard Sarro, Acadia A. Kocher, Deena Emera, Severin Uebbing, Emily V. Dutrow, Scott D. Weatherbee, Timothy Nottoli, James P. Noonan

The paper disrupts the major promoter-enhancer interaction for Pitx1 in mice and finds minimal phenotypic effects despite complete disruption of the topological interaction.

Development · Mar 16, 2018Peer-reviewedGenetics