Elaine A. Ostrander

This study creates a transcriptomic atlas of canine gastric cancer using single-nucleus RNA-sequencing, bulk RNA-sequencing, and spatial transcriptomics, revealing molecular similarities to human disease.

This study imputes ancient dog and wolf genomes to analyze inbreeding history over 10,000 years, finding lower inbreeding in ancient populations and associations between low ROH regions and olfaction/immune genes.

The paper investigates mutation rates in 43 dog breeds, finding stable rates influenced by parental age and breed-specific differences in mutation accumulation.

The paper identifies 15 genetic loci associated with gastric cancer in dogs, highlighting HDAC2, SOX2-OT, and IGF2BP2 as potential risk factors.

This study uses a genotype-first approach to identify new mutations related to craniofacial morphology and stature in dogs, highlighting the role of allelic heterogeneity in breed trait selection.

The paper identifies ten major canine genetic lineages and their behavioral correlates, showing breed diversification is driven by non-coding regulatory variation.

This study examines how age, sex, weight, and breed influence DNA methylomes in canids, finding strong associations with age, sex, and sterilization status, and showing genetic and physiological factors moderate epigenetic aging.

The paper evaluates low-pass whole genome sequencing and imputation in dogs, optimizing variant filtering to reduce imputation error and provides guidelines for GWAS using imputed genotypes.

The paper identifies germline regulatory variants associated with histiocytic sarcoma in flat-coated retrievers using a multi-omics approach and GWAS.

The paper presents an improved long-read assembly of the dog reference genome, significantly enhancing contiguity and gene annotation.

This paper develops epigenetic clocks for dogs to estimate age and mortality risk, and identifies methylation sites linked to breed weight and lifespan.