Kristina Yim

Cell type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development

This study identifies cell type-specific gene expression changes in Chd8 haploinsufficient mouse cortex during development, highlighting dysregulation in progenitors and neurons.

Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment

The paper maps chromatin interactions of Human Accelerated Regions (HARs) in human and chimpanzee neural stem cells to identify gene targets and their role in neurodevelopment.

Human Accelerated Regions regulate gene networks implicated in apical-to-basal neural progenitor fate transitions

The paper identifies human accelerated regions (HARs) that regulate gene networks involved in neural progenitor fate transitions, specifically affecting apical-to-basal polarity and cortical development.

CpG island turnover events predict evolutionary changes in enhancer activity

The paper shows that turnover of CpG islands in enhancers is linked to changes in enhancer activity across mammals, including humans, and contributes to gene regulatory innovation.

Modeling uniquely human gene regulatory function in humanized mice

The paper examines the role of the human-specific enhancer HACNS1 in human evolution by analyzing its effects on gene expression in humanized mice.

Visualizing Structure and Transitions for Biological Data Exploration

The paper introduces PHATE, a visualization method that captures nonlinear structure in biological data, showing it preserves patterns better than existing tools and reveals novel insights in scRNA-seq data.

MAGIC: A diffusion-based imputation method reveals gene-gene interactions in single-cell RNA-sequencing data

MAGIC improves single-cell RNA-seq data by imputing missing values and revealing gene-gene interactions through a diffusion-based method.