Discovery of a small peptide that activates both APCCdc20 and APCCdh1 in yeast, driving increased lifespan
Rachel Elizabeth Harris, Spike D. L. Postnikoff, Nishita K Shukla, Alexandra Harkness, Hannah M. Brooks, Abd-Al-Wahab Khawaja, Mackenzie E. Malo, Carlos Zapien Verdugo, Brandon M. Waddell, Cheng‐Wei Wu, Troy A. A. Harkness
The paper identifies a small peptide, C43-4, that activates the APC Cdh1 complex in yeast, increasing chronological lifespan and showing evolutionary conservation in C. elegans.
bioRxiv · Aug 6, 2026 · PreprintGenetics