GeneticsbioRxivPreprint
Discovery of a small peptide that activates both APCCdc20 and APCCdh1 in yeast, driving increased lifespan
Rachel Elizabeth Harris, Spike D. L. Postnikoff, Nishita K Shukla…·Troy A. A. Harkness
The paper identifies a small peptide, C43-4, that activates the APC Cdh1 complex in yeast, increasing chronological lifespan and showing evolutionary conservation in C. elegans.
DOI 10.64898/2026.02.17.706436