Author

Astrid Feiten

German Center for Neurodegenerative DiseasesORCID 0000-0002-9134-2852Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:proteomics· 1

Frequent Co-Authors

Brigitte NuscheriD· 2 shared Christian HaassiD· 2 shared Joseph W. LewcockiD· 2 shared Kai SchlepckowiD· 2 shared Kathryn M. MonroeiD· 2 shared Lis de WeerdiD· 2 shared Stefan F. LichtenthaleriD· 2 shared Stephan A. MülleriD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersNeuroscience

Brigitte NuscherORCID

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2 papers

Recent·Most cited

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

Astrid Feiten, Kilian Dahm, Kai Schlepckow, Bettina van Lengerich, Jung H. Suh, Anika Reifschneider, Benedikt Wefers, Laura M. Bartos, Karin Wind-Mark, Lis de Weerd, T Ulas, Elena De Domenico, Pia Grundschöttel, Stefan Paulusch, Benjamin Tast, , Christian Haass

This study investigates how TREM2 expression levels affect microglial function, metabolism, and response to TREM2 agonists in a mouse model of Alzheimer's disease.

Nature Communications · Jan 24, 2026Peer-reviewedNeuroscience

Anti-Aβ immunotherapy-mediated amyloid clearance attenuates microglial activation without inducing exhaustion at residual plaques

Lis de Weerd, Selina Hummel, Stephan A. Müller, Iñaki Paris, Thomas Sandmann, Marie Eichholtz, Robin Gröger, Amelie L. Englert, Stephan Wagner, Connie Ha, Sonnet S. Davis, Valerie Warkins, Dan Xia, Brigitte Nuscher, Anna Berghofer, , Christian Haass

This study shows that long-term anti-Aβ treatment reduces amyloid plaques and microglial activation but leaves residual plaques with persistent immune activity.

bioRxiv · Apr 10, 2025 · PreprintNeuroscience