IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity
Bilge Askin, Cagla Kilic, César Cordero Gómez, Sophie Lan-Linh Duong, Alvaro Dominguez‐Baquero, Alexander Goihl, Karsten Nalbach, Joana Petushi, Pia Grundschöttel, Jessica Wagner, Valentine Thomas, Janne Lamberty, Emily Withers, Hanna Huber, Sabrina Hübschmann, , Susanne Wegmann
This study shows that IgLON5 autoantibodies cause neuronal hyperactivity and Tau pathology by clustering cell surface proteins, linking them to neurodegeneration.
Science Advances · May 13, 2026Peer-reviewedNeuroscience