Kathryn M. Monroe

Chronic NLRP3 inflammasome activation drives neutrophil brain entry and interactions with microglia

This study shows chronic NLRP3 inflammasome activation leads to neutrophil entry into the brain and interactions with microglia, contributing to CNS pathology.

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

This study investigates how TREM2 expression levels affect microglial function, metabolism, and response to TREM2 agonists in a mouse model of Alzheimer's disease.

Anti-Aβ immunotherapy-mediated amyloid clearance attenuates microglial activation without inducing exhaustion at residual plaques

This study shows that long-term anti-Aβ treatment reduces amyloid plaques and microglial activation but leaves residual plaques with persistent immune activity.

GPR34 regulates microglia state and loss-of-function rescues TREM2 metabolic dysfunction

This study shows that GPR34 regulates microglia function and loss-of-function in TREM2 KO microglia rescues cholesterol metabolism, suggesting GPR34 as a therapeutic target for Alzheimer's disease.

Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology

This study shows that TREM2 deficiency reduces microglial hyperactivation in GRN-deficient models but does not rescue lysosomal dysfunction or neurodegeneration biomarkers.