BiochemistryJournal of Biological ChemistryPeer-reviewed
Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain
Francesco Agostini, Leonardo Pereyra, Justin Dale…·Nuno Raimundo
The paper identifies that lysosomal defects up-regulate cholesterol synthesis via mitochondrial respiratory chain interactions and Ca2+ retention, while mitochondrial defects down-regulate it.
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