Author

Alfonso Schiavi

Leibniz Institute of Environmental MedicineORCID 0000-0002-6563-8035Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Natascia VenturaiD· 3 shared Silvia MaglioniiD· 2 shared Vanessa BrinkmanniD· 2 shared Anna LaromaineiD· 1 shared Anne Hemmers· 1 shared Antonio Miranda‐VizueteiD· 1 shared Brian McDonaghiD· 1 shared Charlotte EsseriD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenetics

Natascia VenturaORCID

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Author profile →

3 papers

Recent·Most cited

Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans

Marina Valenzuela-Villatoro, Patricia de la Cruz Ruiz, David Guerrero‐Gómez, Eva Gómez‐Orte, Alfonso Schiavi, Silvia Maglioni, Mayte Montero, Rosalba I. Fonteríz, José C. Casas-Martinez, Nicole E. Briand, Jingxiu Xu, María Jesús Rodríguez‐Palero, Marta Artal‐Sanz, Katarzyna Olek, Justyna Polaczyk, , Antonio Miranda‐Vizuete

This study shows that loss of mitochondrial glutathione reductase and thioredoxin reductase in C. elegans causes growth, fertility, and muscle defects, activates a constitutive UPRmt, and alters mitochondrial morphology.

Redox Biology · Mar 9, 2026Peer-reviewedGenetics

Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans

Silvia Maglioni, Alfonso Schiavi, Marlen Melcher, Vanessa Brinkmann, Zhongrui Luo, Anna Laromaine, Nuno Raimundo, Joel N. Meyer, Felix Distelmaier, Natascia Ventura

This study identifies lutein as a potential therapeutic for mitochondrial dysfunction-induced neurodevelopmental defects in C. elegans by restoring neuroligin expression.

Nature Communications · May 12, 2022Peer-reviewedNeuroscience

Aryl hydrocarbon receptor-dependent and -independent pathways mediate curcumin anti-aging effects

Vanessa Brinkmann, Margherita Romeo, Lucie Larigot, Anne Hemmers, Lisa Tschage, Jennifer Kleinjohann, Alfonso Schiavi, Swantje Steinwachs, Charlotte Esser, Ralph Menzel, Sara Giani Tagliabue, Laura Bonati, Fiona Frederike Cox, Niloofar Ale‐Agha, Philipp Jakobs, , Natascia Ventura

This study investigates how curcumin's anti-aging effects are mediated through AhR-dependent and -independent pathways in different contexts.

Antioxidants · Mar 23, 2022Peer-reviewedMolecular Biology