Author

Francesco Agostini

University of PaduaORCID 0000-0002-9833-6498Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Elisa GreggioiD· 2 shared Federica De LazzariiD· 2 shared Laura CivieroiD· 2 shared Marco BisagliaiD· 2 shared Nicoletta PlotegheriD· 2 shared Alexandra G. BeilinaiD· 1 shared Bibiana SgallettaiD· 1 shared Chiara SinisgalliiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCell Biology

Elisa GreggioORCID

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2 papers

Recent·Most cited

Parkinson disease-associated protein DJ-1 regulates the autophagic-lysosomal pathway through ROS-dependent modulation of the AMPK/mTORC1 axis.

Francesco Agostini, Federica De Lazzari, Alexandra G. Beilina, Bibiana Sgalletta, Chiara Sinisgalli, Elena Giusto, Laura Civiero, Luigi Bubacco, Mark Cookson, Nicoletta Plotegher, Elisa Greggio, Marco Bisaglia

This study shows that DJ-1 deficiency impairs autophagosome-lysosome fusion and lysosomal degradation, leading to autophagic substrate accumulation through ROS-dependent modulation of the AMPK/mTORC1 axis in Parkinson's disease.

bioRxiv · Apr 13, 2026 · PreprintCell Biology

PAK6 promotes neuronal autophagy by regulating TFEB nuclear translocation.

Francesco Agostini, Rossella Agostinis, Martina Di Rocco, Sandro Montefusco, Giulia Tombesi, Lucia Iannotta, Susanna Cogo, Federica De Lazzari, Isabella Tessari, Laura Civiero, Evy Lobbestael, Veerle Baekelandt, Gabriele Sales, Diego Luis Medina, Xiaomeng Zhang, , Elisa Greggio

This study identifies PAK6 as a positive regulator of neuronal autophagy through TFEB nuclear translocation, with implications for neurodegenerative disease treatment.

bioRxiv · Jun 5, 2024 · PreprintNeuroscience