A human-specific enhancer fine-tunes radial glia potency and corticogenesis
Jing Liu, Federica Mosti, Hanzhi Zhao, Davoneshia Lollis, Jesús Emiliano Sotelo-Fonseca, Carla F. Escobar-Tomlienovich, Camila Manso Musso, Yiwei Mao, Abdull J. Massri, Hannah M. Doll, Nicole D. Moss, André M. M. Sousa, Gregory A. Wray, Ewoud R.E. Schmidt, Debra L. Silver
The paper shows human-specific variants in HARE5 enhance enhancer activity, promoting progenitor proliferation and contributing to human cortical expansion.
Nature · May 14, 2025Peer-reviewedNeuroscience