Cleavage of the TrkB-FL Receptor During Epileptogenesis: Insights from a Kainic Acid-Induced Model of Epilepsy and Human Samples
Leonor Ribeiro‐Rodrigues, João Fonseca‐Gomes, Sara L. Paulo, Ricardo Viais, Filipa F. Ribeiro, Catarina Miranda‐Lourenço, Francisco M. Mouro, Rita F. Belo, Catarina B. Ferreira, Sara Ramalho Tanqueiro, Mafalda Ferreira-Manso, Juzoh Umemori, Eero Ċastrén, Vítor H. Paiva, Ana Maria Sebastião, , Maria José Diógenes
This study investigates TrkB-FL cleavage and TrkB-ICD formation during epileptogenesis in a rat model and human samples, finding a correlation with seizure severity and memory impairment.
Pharmacological Research · Mar 19, 2025Peer-reviewedNeuroscience