Ana Maria Sebastião

This study investigates TrkB-FL cleavage and TrkB-ICD formation during epileptogenesis in a rat model and human samples, finding a correlation with seizure severity and memory impairment.

This study shows BDNF increases synaptic GluN2B-containing NMDA receptors, which mediates synaptic plasticity and contributes to epileptogenesis.

This study shows BDNF enhances oligodendrogenesis from SVZ-NSCs, with A2AR antagonism blocking this effect, suggesting their interaction modulates differentiation.

This study shows that inhibiting cannabinoid type 2 receptors combined with physical exercise reduces stress-induced emotional and cognitive deficits and enhances adult hippocampal neurogenesis.

This study investigates CBDV's effect on SVZ neurogenesis, showing it promotes neuronal differentiation and inhibits oligodendrocyte differentiation via TRPV1.

This study examines adenosine and VEGF signaling changes in SOD1G93A mice with and without chronic caffeine treatment, finding early adenosinergic dysfunction and caffeine's impact on BDNF levels.

This study shows that astrocytes are necessary for BDNF-enhanced hippocampal LTP, but only under specific stimulation conditions.

This study shows that loss of Rhoa in microglia causes neurodegeneration through Src-mediated Tnf production and excitotoxic glutamate secretion.