Miranda Mele

Disease-associated variants alter a novel physiological role of hnRNP H2 in neuronal development

This study identifies hnRNP H2's role in neuronal development and shows how disease variants disrupt its function, leading to neurodevelopmental defects.

BDNF-TrkB signaling promotes synaptic GluN2A-NMDA receptor expression and network hyperexcitability in cultured hippocampal neurons and during status epilepticus

Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons

This study shows that activating the 20S proteasome core particle prevents cell death in cortical neurons under oxygen- and glucose-deprivation conditions.

Synaptic accumulation of GluN2B-containing NMDA receptors mediates the effects of BDNF-TrkB signalling on synaptic plasticity and in epileptogenesis

This study shows BDNF increases synaptic GluN2B-containing NMDA receptors, which mediates synaptic plasticity and contributes to epileptogenesis.