Juzoh Umemori

This study investigates TrkB-FL cleavage and TrkB-ICD formation during epileptogenesis in a rat model and human samples, finding a correlation with seizure severity and memory impairment.

This study shows chronic fluoxetine reduces mitochondrial activity in parvalbumin interneurons of the prefrontal cortex, potentially leading to disinhibition and enhanced synaptic plasticity.

This study shows that TrkB-mediated plasticity in Somatostatin-expressing neurons is critical for the extinction of cocaine-seeking behavior and preventing relapse.

This study identifies specific projection targets of VTA Sst neurons and shows their role in stress-related behaviors and drug responses.

This study shows that TrkB activation in PV+ interneurons is essential for antidepressant-induced behavioral flexibility and synaptic plasticity in spatial and fear memory.

The paper uses optogenetics to activate TrkB receptors in the ventral hippocampus, enhancing plasticity and improving fear extinction in mice.

This study shows that chondroitinase and antidepressants promote plasticity in the adult visual cortex by enhancing TRKB signaling in parvalbumin neurons through inhibition of PTPσ.

The paper shows that optogenetic activation of TrkB receptors in PV interneurons increases cortical plasticity by altering neuronal excitability and gene expression.