Anterior insular CB1 receptor signaling selectively regulates social novelty and anxiety-related behaviors
Elena Martín‐García, Paula Mut-Arbona, Guilherme Horta, Anna Bagó-Mas, Alejandra García‐Blanco, Petri Turunen, Michael J. Schmeißer, Iñigo Ruı́z de Azúa, Beat Lutz, Rafael J. Maldonado
This study shows that restoring CB1R in the anterior insular cortex of CB1R-deficient mice normalizes social novelty discrimination and reduces anxiety-like behavior without affecting other behaviors.
bioRxiv · Mar 25, 2026 · PreprintNeuroscience