Age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death
Tim Baldensperger, Tobias Jung, Tom Heinze, Tanja Schwerdtle, Annika Höhn, Tilman Grune
This study isolates authentic lipofuscin from cardiac tissue and shows it induces oxidative stress, lysosomal dysfunction, and pyroptotic cell death in fibroblasts.
Free Radical Biology and Medicine · Oct 31, 2024Peer-reviewedCell Biology