Tilman Grune

The paper shows that primary cilia regulate programmed cell death by controlling the proteasomal degradation of MOAP1 through ciliopathy proteins like RPGRIP1L, TCTN1, and CEP290.

This paper introduces TSIT, a method to assess mitochondrial function in frozen cardiac tissue, showing comparable results to fresh samples and detecting dysfunction in various mouse models and human samples.

This study isolates authentic lipofuscin from cardiac tissue and shows it induces oxidative stress, lysosomal dysfunction, and pyroptotic cell death in fibroblasts.