Cell BiologyFree Radical Biology and MedicinePeer-reviewed
Age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death
Tim Baldensperger, Tobias Jung, Tom Heinze…·Tilman Grune
This study isolates authentic lipofuscin from cardiac tissue and shows it induces oxidative stress, lysosomal dysfunction, and pyroptotic cell death in fibroblasts.