This study investigates genetic changes in Svalbard reindeer due to historical overharvesting using ancient and modern genomes, showing reduced genetic diversity and altered allele frequencies.

Molecular Ecology · Jan 27, 2024Peer-reviewedGenomics

Population genomics reveals extensive inbreeding and purging of mutational load in wild Amur tigers

Tianming Lan, Haimeng Li, Le Zhang, Minhui Shi, Boyang Liu, Liangyu Cui, Nicolás Dussex, Qing Wang, Yue Ma, Dan Liu, Weiyao Kong, Jiangang Wang, Haorong Lu, Shaofang Zhang, Jieyao Yu, , Yanchun Xu

This study finds higher inbreeding and purging of mutational load in wild Amur tigers compared to captive individuals, suggesting purifying selection reduces deleterious alleles in wild populations.

bioRxiv · May 9, 2023 · PreprintGenomics

GenErode: a bioinformatics pipeline to investigate genome erosion in endangered and extinct species

Verena Esther Kutschera, Marcin Kierczak, Tom van der Valk, Johanna von Seth, Nicolás Dussex, Edana Lord, Marianne Dehasque, David W. G. Stanton, Payam Emami Khoonsari, Björn Nystedt, Love Dalén, David Díez‐del‐Molino

GenErode provides a pipeline to analyze genomic erosion by comparing ancient and modern whole-genome re-sequencing data, producing standardized erosion indices.

BMC Bioinformatics · Jun 13, 2022Peer-reviewedBioinformatics

The tuatara genome: insights into vertebrate evolutionfrom the sole survivor of an ancient reptilian order

Neil J. Gemmell, Kim Rutherford, Stefan Prost, Marc Tollis, David J. Winter, Jonathan R. Macey, David L. Adelson, Alexander Suh, Terry Bertozzi, José Horacio Grau, Chris L. Organ, Paul P. Gardner, Matthieu Muffato, Mateus Patrício, Konstantinos Billis, , Ngatiwai Trust Board

The paper presents the tuatara genome, highlighting its evolutionary significance and unique features compared to other vertebrates.

bioRxiv · Dec 8, 2019 · PreprintGenomics