Bastian Schiffthaler

Single-Cell and Tissue-Specific CRISPR Editing Analyses Unveil New Insights to Off-Targets and Translocations

The paper analyzes CRISPR-Cas9 off-target mutations and translocations at single-cell and tissue-specific levels in mice, revealing context-dependent variability in editing outcomes.

SNP panel for non-invasive genotyping of leopard (Panthera pardus)

The paper develops a species-specific SNP panel for non-invasive leopard genotyping, validated for global range and low DNA content samples.

Essentiality of LD-Transpeptidation in Agrobacterium tumefaciens

This study identifies the essential role of LD-transpeptidation in Agrobacterium tumefaciens cell wall integrity and growth by analyzing LDTs and their genetic interactions.

An Improved Chromosome-scale Genome Assembly and Population Genetics resource for Populus tremula.

The paper presents an improved chromosome-scale genome assembly for Populus tremula and integrates population genetics and genomics data to study leaf physiognomy traits through GWAS and functional analysis.

Simultaneous inhibition of DNA-PK and Pol{Theta} improves integration efficiency and precision of genome editing

This study identifies AZD7648 and Pol{Theta} inhibitors as a combination (2iHDR) that enhances CRISPR-Cas9 integration efficiency and precision by targeting DNA-PK and MMEJ repair pathways.

Seidr: Efficient Calculation of Robust Ensemble Gene Networks

Seidr is a toolkit for gene regulatory and co-expression network inference that reduces algorithmic bias and improves robustness across species and conditions.

The mitogenome of Norway spruce and a reappraisal of mitochondrial recombination in plants

The paper assembles the Norway spruce mitogenome using machine learning and long reads, revealing heterogeneous recombination dynamics and active small repeats in plant mitogenomes.

An ultra-dense haploid genetic map for evaluating the highly fragmented genome assembly of Norway spruce (Picea abies)

The paper creates an ultra-dense haploid genetic map for Norway spruce to improve genome assembly and evaluate gene distribution across chromosomes.

Interspecific plastome recombination reflects ancient reticulate evolution in Picea (Pinaceae)

The paper analyzes plastomes of 65 Picea accessions to find evidence of interspecific recombination and hybridization, challenging assumptions about uniparental plastid inheritance and recombination.