Haorong Lu

This study characterizes the urinary microbiome in 1579 Chinese individuals, identifying host factors and genetic associations that influence microbial composition and urotype classification.

The paper presents a telomere-to-telomere genome assembly for Oryza longistaminata, revealing structural variations and gene duplications that may contribute to its advantageous traits.

The paper creates a high-resolution spatial transcriptomic atlas of the mouse brain using snRNA-seq and Stereo-seq, identifying new cell clusters, region-specific genes, and transcription factor regulons.

This study reveals deep genetic differentiation in Malayan pangolins, identifies two new genetic populations, and proposes a new species closely related to the Philippine pangolin.

This study finds higher inbreeding and purging of mutational load in wild Amur tigers compared to captive individuals, suggesting purifying selection reduces deleterious alleles in wild populations.

This study analyzes cell-free DNA in COVID-19 patients to show its potential for disease monitoring and tissue injury assessment.

This study uses Mendelian randomization to identify causal relationships between gut microbiome composition and blood metabolites in a Chinese cohort.

This study identifies genetic loci associated with the oral microbiome using metagenome-genome-wide association studies in over 1,915 individuals.

This study uses Stereo-seq to generate high-resolution spatiotemporal transcriptomic maps of Drosophila embryos and larvae, revealing new subregions and gene regulatory networks.

The paper analyzes the genetic diversity of HPV types 16, 18, 52, and 58 in southern China, identifying sublineages and mutations associated with oncogenic potential.

This study assembled two chromosome-scale genomes of the fall armyworm in China, revealing gene family expansions and population origins to aid in pest management.

The paper introduces scCAT-seq, a method to simultaneously assay chromatin accessibility and transcriptome in single cells, and demonstrates its application in human pre-implantation embryos to reveal regulatory heterogeneity.