Author

Kirk Deitsch

Weill Cornell MedicineORCID 0000-0002-9183-2480Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Joseph E. VisoneiD· 3 shared Björn F. C. KafsackiD· 2 shared Evi HadjimichaeliD· 2 shared Francesca FloriniiD· 2 shared Abbas Roayaei Ardakany· 1 shared Abhijit ChakrabortyiD· 1 shared Akshay VishwanathaiD· 1 shared Amanda Michele Chan· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersMicrobiology

Joseph E. VisoneORCID

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Author profile →

5 papers

Recent·Most cited

Plasmodium falciparum DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification

Akshay Vishwanatha, Xu Zhang, Yi Jing Liu, Annie Leung, Mikayla Herring, Joseph E. Visone, Amanda Michele Chan, Susanah Calhoun, Kirk Deitsch, Laura A. Kirkman

This study investigates DNA repair dynamics in Plasmodium falciparum, revealing distinct roles for TLS polymerases and PfRad51 in maintaining chromosomal structure and genome diversification.

Nucleic Acids Research · Nov 13, 2025Peer-reviewedMicrobiology

The molecular basis of coordinated antigen switching enabling chronic infection by human malaria parasites

Joseph E. Visone, Francesca Florini, Evi Hadjimichael, Valay Patel, Kirk Deitsch

This study identifies the molecular mechanism by which var2csa functions as a switching hub to coordinate var gene expression in Plasmodium falciparum, enabling antigenic variation and chronic infection.

bioRxiv · Jul 16, 2025 · PreprintMicrobiology

Transcriptional plasticity of virulence genes provides malaria parasites with greateradaptive capacity for avoiding host immunity

Francesca Florini, Joseph E. Visone, Evi Hadjimichael, Shivali Malpotra, Christopher Nötzel, Björn F. C. Kafsack, Kirk W. Deitsch

This study reveals that Plasmodium falciparum parasites can express multiple var genes or suppress var gene expression, enabling them to evade host immunity and persist in chronic infections.

bioRxiv · Mar 8, 2024Microbiology

Chromatin structure and var2csa - a tango in regulation of var gene expression in the human malaria parasite Plasmodium falciparum?

Todd Lenz, Xu Zhang, Abhijit Chakraborty, Abbas Roayaei Ardakany, Jacques G. Prudhomme, Ferhat Ay, Kirk Deitsch, Karine G. Le Roch

The paper investigates how var2csa influences var gene expression in Plasmodium falciparum by analyzing chromatin structure changes after gene deletion.

bioRxiv · Feb 13, 2024 · PreprintSystems Biology

Metabolic competition between lipid metabolism and histone methylation regulates sexual differentiation in human malaria parasites.

Chantal T. Harris, Xinran Tong, Riward Campelo Morillo, Leen N. Vanheer, Inês M. Marreiros, Navid Nahiyaan, Vanessa Zuzarte‐Luís, Kirk Deitsch, Maria M. Mota, Kyu Young Rhee, Björn F.C. Kafsack

The paper shows that metabolic competition for S-adenosylmethionine between histone methyltransferases and phosphoethanolamine methyltransferase regulates sexual differentiation in Plasmodium falciparum.

bioRxiv · Jan 18, 2022 · PreprintSystems Biology