Kyu Young Rhee

This study identifies PspA's role in maintaining membrane potential and supporting NADH dehydrogenase function in mycobacteria through interactions with PspM and menaquinone.

This study shows desiccation-induced DNA damage in Mtb leads to mutations and drug resistance by affecting DNA repair and gene expression.

The paper profiles gut bacterial extracellular vesicles (bEVs) and links their cargo composition to host transcriptional responses across different cell types.

This study identifies the PE22/PPE36 complex in Mycobacterium tuberculosis as a sulfate uptake system, showing its role in sulfur acquisition and metabolic homeostasis.

The paper identifies Rv2571c as a mycobacterial ion channel that mediates pyrazinamide resistance by regulating cytoplasmic acidification.

The paper introduces e3SIM, a simulator that models epidemiological, ecological, and evolutionary processes in pathogens, demonstrating its use with SARS-CoV-2 and Mycobacterium tuberculosis.

The paper maps unknown lipids in bacterial pathogens using lipidomic methods, revealing new biosynthetic products linked to virulence.

The paper identifies genes in Mycobacterium tuberculosis essential for intra-alveolar survival after airborne transmission, revealing stage-specific roles in transmission.

This study introduces DECIPHAER, a tool that identifies critical mechanisms of tuberculosis drug action by integrating multi-modal data, revealing that respiration inhibition is more impactful than cell wall effects.

This paper identifies GlmU as a critical enzyme inhibited by sugar phosphates in Vibrio cholerae, linking glucose metabolism to cell envelope integrity and antibiotic susceptibility.

This study identifies a novel mechanism by which rifampin shortens TB treatment by inhibiting Mtb RNA polymerase, leading to cell division arrest and reduced antibiotic resistance.

This study identifies a periplasmic protein complex in Mtb that supports arabinofuranosyltransferase activity and contributes to intrinsic drug resistance.

This study identifies a candidate transmission survival genome of Mycobacterium tuberculosis by exposing it to model aerosol fluid and analyzing gene contributions to survival during transmission.

The paper identifies CoaX, a pseudokinase, and pantothenate as regulators of proteasomal degradation of the pantothenate synthesis enzyme PanB in M. tuberculosis.

This paper shows that deletion of the yqgC-sodA operon in Bacillus subtilis causes Mn sensitivity by reducing Mn efflux and inhibiting Mg-dependent enzymes, distinct from efflux-deficient mutants.

The paper uses transposon mutagenesis and QTL mapping to identify host-pathogen genetic interactions affecting Mtb fitness in immunodivergent mice.

The paper investigates the evolution and regulation of rhamnolipid biosynthesis in Pseudomonas aeruginosa, linking it to oxidative stress and explaining its inconsistent distribution across lineages.

The paper introduces PLUMAPs, a tool that visualizes protein similarity using protein language models, dimensionality reduction, and topic modeling, showing improved clustering and interpretability compared to traditional sequence similarity networks.

The paper shows that metabolic competition for S-adenosylmethionine between histone methyltransferases and phosphoethanolamine methyltransferase regulates sexual differentiation in Plasmodium falciparum.

This study identifies ANKH's role in extracellular citrate and pyrophosphate homeostasis and its impact on bone mechanical properties.