Author

Aguirre A. de Cubas

Medical University of South CarolinaORCID 0000-0002-9185-9544Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Bryan GrangeriD· 1 shared Eva AlleniD· 1 shared Leonardo M. R. FerreiraiD· 1 shared Martin J. RomeoiD· 1 shared Rob A. RobinoiD· 1 shared Russell W CochraneiD· 1 shared Silvia G. VaenaiD· 1 shared Stefano BertoiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperImmunology

Bryan GrangerORCID

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1 paper

Recent·Most cited

High affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells

Russell W Cochrane, Rob A. Robino, Bryan Granger, Eva Allen, Silvia G. Vaena, Martin J. Romeo, Aguirre A. de Cubas, Stefano Berto, Leonardo M. R. Ferreira

This study shows that high-affinity CAR signaling in human Tregs leads to increased cytotoxicity and inflammatory cytokine production, while lower affinity reduces these effects.

Molecular Therapy — Methods & Clinical Development · Nov 18, 2024Peer-reviewedImmunology