Author

Ashley Emily Siegel

Brigham and Women's HospitalORCID 0000-0002-1435-1624Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

David E. MaridasiD· 2 shared Pratik KoiralaiD· 2 shared Samerender Nagam HanumantharaoiD· 2 shared Shailesh AgarwaliD· 2 shared Vicki RoseniD· 2 shared Yuji M. MishinaiD· 2 shared Ziyu CheniD· 2 shared Chang LiuiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

David E. MaridasORCID

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3 papers

Recent·Most cited

Cell BiologyiSciencePeer-reviewedJul 1, 2026

A closed-loop cell therapy engineered to autonomously secrete Activin A inhibitor protects from fibrodysplasia ossificans progressiva

Pratik Koirala, Ziyu Chen, Mengfan Wu…·Shailesh Agarwal

This paper develops a closed-loop cell therapy that secretes an Activin A inhibitor to prevent heterotopic bone formation in a mouse model of FOP.

DOI 10.1016/j.isci.2026.116602

mouseexperimental assay

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Cell BiologybioRxivPreprintMar 16, 2026

Activation of PPARγ redirects fibro-adipogenic progenitors to replace ectopic bone with fat in models of fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification

Pratik Koirala, Ziyu Chen, Samerender Nagam Hanumantharao…·Shailesh Agarwal

This study identifies rosiglitazone, a PPARγ agonist, as a potential therapy for fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification by converting ectopic bone to fat.

DOI 10.64898/2026.02.26.708276

mousestatistical model

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GeneticsThe American Journal of Human GeneticsPeer-reviewedOct 23, 2020

Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model

Fayçal Guedj, Ashley Emily Siegel, Jeroen L. A. Pennings…·Diana W. Bianchi

Apigenin improved oxidative stress and behavior in Down syndrome models but had no significant birth defects.

32 citations

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