Will Edward Hinckley

HHO5: A key orchestrator of dose-dependent nitrogen signaling pathways in Arabidopsis

This study identifies HHO5 as a dual activator/repressor of nitrogen signaling in Arabidopsis, showing its dose-dependent regulation and role in gene networks.

Transcription Factor (TF) validation using Dam-IT simultaneously captures genome-wide TF-DNA binding, direct gene regulation, and chromatin accessibility in plant cells

This paper introduces Dam-IT, a method that simultaneously captures TF-DNA binding, direct gene regulation, and chromatin accessibility, revealing the 'Hit-and-Run' mechanism of transcription by bZIP1.

Uncovering the "ZIP code" for bZIP dimers reveals novel motifs, regulatory rules and one billion years of cis-element evolution

The paper develops dDAP-seq to study bZIP heterodimer DNA binding in Arabidopsis, revealing expanded binding preferences and evolutionary origins of cis-elements.

Regulatory start-stop elements in 5' untranslated regions pervasively modulate translation

The paper identifies start-stop elements in 5' UTRs that repress translation by halting ribosomes, showing their prevalence in human genes and impact on cellular processes.