Author

Pierre Klein

The Francis Crick InstituteORCID 0000-0002-9209-2939Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Raphaëlle LuisieriD· 2 shared Rickie PataniiD· 2 shared Andres RamosiD· 1 shared Anob M. ChakrabartiiD· 1 shared Denis FurlingiD· 1 shared Doaa M. TahaiD· 1 shared Frédérique RauiD· 1 shared Giulia E. TyzackiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMolecular Biology

Raphaëlle LuisierORCID

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3 papers

Recent·Most cited

Single-nucleotide resolution profiling reveals dynamic and site-specific m⁶A regulation during human myogenesis

Pierre Klein, Krizia Ronquillo, Ludovic Arandel, Frédérique Rau, Denis Furling

The paper maps single-nucleotide resolution m⁶A methylation in human myogenic differentiation, revealing dynamic epitranscriptomic changes and species-specific patterns.

bioRxiv · Jan 12, 2026 · PreprintMolecular Biology

m6a methylation orchestrates IMP1 regulation of microtubules during human neuronal differentiation

Pierre Klein, Jasmine Harley, Harry Crook, Sofia Esteban Serna, Marija Petrić, Theodoros I. Roumeliotis, Jyoti Sharma Choudhary, Anob M. Chakrabarti, Raphaëlle Luisier, Rickie Patani, Andres Ramos

The paper shows m6A methylation guides IMP1's regulation of microtubule-related mRNAs during human neuronal differentiation.

bioRxiv · Sep 12, 2023 · PreprintMolecular Biology

An aberrant cytoplasmic intron retention programme is a blueprint for ALS-related RBP mislocalization

Giulia E. Tyzack, Jacob Neeves, Pierre Klein, Hamish Crerar, Oliver Jonathan Ziff, Doaa M. Taha, Raphaëlle Luisier, Nicholas M. Luscombe, Rickie Patani

The paper identifies aberrant cytoplasmic intron-retaining transcripts (IRTs) in ALS and shows their association with RBP mislocalization.

bioRxiv · Jul 20, 2020 · PreprintNeuroscience