Author

Hamish Crerar

The Francis Crick InstituteORCID 0000-0002-3607-0698Unclaimed ORCID profile · follow to get notified of new preprints

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Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Organism:human· 3 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Raphaëlle LuisieriD· 3 shared Rickie PataniiD· 3 shared Giulia E. TyzackiD· 2 shared Jacob NeevesiD· 2 shared Marija PetrićiD· 2 shared Nicholas M. LuscombeiD· 2 shared Adolfo SaiardiiD· 1 shared Antonella RiccioiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

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10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Raphaëlle LuisierORCID

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4 papers

Recent·Most cited

Toxicity of MAPT 4R RNA Contributes to Motor Neuron Degeneration in ALS

Hamish Crerar, Michele Stasi, Koustav Pal, Sabrina Pia Nuccio, Marija Petrić, Giulia Manferrari, Yiran Wang, Benjamin E. Clarke, Marc‐David Ruepp, Marco Di Antonio, Rickie Patani

The paper shows that increased 4R Tau RNA contributes to motor neuron degeneration in ALS by reducing viability and that targeting this RNA could be therapeutic.

bioRxiv · Sep 29, 2026 · PreprintNeuroscience

3’UTR cleavage of transcripts localized in axons of sympathetic neurons

Catia Andreassi, Raphaëlle Luisier, Hamish Crerar, Marousa Darsinou, Sasja Blokzijl-Franke, Tchern Lenn, Nicholas M. Luscombe, Giovanni Cuda, Marco Gaspari, Adolfo Saiardi, Antonella Riccio

The paper shows that 3UTR cleavage occurs in sympathetic neuron axons, mediated by Ago2 and HuD, and regulates local protein synthesis and generates new 3UTR RNA fragments.

Cell Reports · Feb 1, 2021Peer-reviewedNeuroscience

Diminished miRNA activity is associated with aberrant cytoplasmic intron retention in ALS pathogenesis

Marija Petrić, Hamish Crerar, Jacob Neeves, Giulia E. Tyzack, Rickie Patani, Raphaëlle Luisier

The paper identifies cytoplasmic intron-retaining transcripts (IRTs) associated with miRNA activity changes in ALS, showing VCP mutations increase IR and target gene expression.

bioRxiv · Jan 27, 2021 · PreprintNeuroscience

An aberrant cytoplasmic intron retention programme is a blueprint for ALS-related RBP mislocalization

Giulia E. Tyzack, Jacob Neeves, Pierre Klein, Hamish Crerar, Oliver Jonathan Ziff, Doaa M. Taha, Raphaëlle Luisier, Nicholas M. Luscombe, Rickie Patani

The paper identifies aberrant cytoplasmic intron-retaining transcripts (IRTs) in ALS and shows their association with RBP mislocalization.

bioRxiv · Jul 20, 2020 · PreprintNeuroscience