Activation of Sarm1 produces cADPR to increase intra-axonal calcium and promote axon degeneration in CIPN
Yihang Li, Maria F. Pazyra‐Murphy, Daina Zofija Avizonis, Mariana De Sa Tavares Russo, Sophia Tang, Chiung-Ya Chen, Yi‐Ping Hsueh, Johann S. Bergholz, Tao Jiang, Jean J. Zhao, Jian Zhu, Kwang Woo Ko, Jeffrey Milbrandt, Aaron DiAntonio, Rosalind A. Segal
This study shows that paclitaxel induces cADPR production via Sarm1, increasing intra-axonal calcium and causing axon degeneration, with cADPR antagonists preventing neuropathy without affecting chemotherapy efficacy.
The Journal of Cell Biology · Dec 8, 2021Peer-reviewedNeuroscience