α-synucleinopathy associated calcium overload and autophagy failure is regulated by gain-of-function of Tousled-like kinase
Fangyan Gong, Hao Chen, Ying Xiong, Rong Cai, Jing Zhang, Ningli Wang, Lei Liu
The paper identifies TLK2 as a key regulator of calcium overload-induced mitochondrial and autophagy dysfunction in Parkinson's disease using Drosophila and mammalian models.
bioRxiv · Jul 17, 2022 · PreprintNeuroscience