Cancer BiologybioRxivPreprint
Increased dosage of wild-type KRAS protein drives KRAS-mutant lung tumorigenesis and drug resistance
Tonči Ivanišević, Wout Magits, Yan Ma…·Anna A. Sablina
This study shows that increased wild-type KRAS protein dosage in KRAS-mutant lung cancer drives tumor growth and drug resistance, with vascular changes mediated by mTOR pathway activation.
3 citations