Author

Paul Nurse

The Francis Crick InstituteORCID 0000-0002-9244-7787Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:yeast· 3 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

Nitin KapadiaiD· 2 shared Tania AuchynnikavaiD· 2 shared Emma L. RobertsiD· 1 shared Joseph F. CurraniD· 1 shared Sarah WillichiD· 1 shared Souradeep BasuiD· 1 shared Theresa U. ZeisneriD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

7 top collaborators · 7 mutual co-author links

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2 shared papersCell Biology

Nitin KapadiaORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

AlphaFold-Multimer reveals diverse cyclin-CDK substrate docking interactions

Sarah Willich, Nitin Kapadia, Paul Nurse

The paper uses AlphaFold-Multimer to predict interactions between cyclin-CDK complexes and substrates, identifying a new docking motif and showing motif-specific phosphorylation preferences.

bioRxiv · Jun 30, 2026 · PreprintCell Biology

Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle

Theresa U. Zeisner, Tania Auchynnikava, Emma L. Roberts, Paul Nurse

The paper shows phosphatase specificity affects CDK substrate phosphorylation timing during G2 and mitosis in fission yeast, establishing different phosphorylation thresholds at the G2/M transition.

Nature Communications · Nov 24, 2025Peer-reviewedCell Biology

Control of CDK activity and the cell cycle by CKS proteins

Joseph F. Curran, Souradeep Basu, Tania Auchynnikava, Paul Nurse

This study identifies CKS proteins as multifaceted regulators of the cell cycle by modulating CDK activity and phosphorylation across diverse processes.

bioRxiv · Jul 4, 2025 · PreprintCell Biology

Spatiotemporal Orchestration of Mitosis by Cyclin-Dependent Kinase

Nitin Kapadia, Paul Nurse

This study shows CDK activation starts in the nucleus, not the cytoplasm, and reveals spatial differences in bistable responses during mitotic onset in fission yeast.

Nature · Jun 25, 2025Peer-reviewedCell Biology