Nitin Kapadia

The paper uses AlphaFold-Multimer to predict interactions between cyclin-CDK complexes and substrates, identifying a new docking motif and showing motif-specific phosphorylation preferences.

This study shows CDK activation starts in the nucleus, not the cytoplasm, and reveals spatial differences in bistable responses during mitotic onset in fission yeast.

The paper uses single-molecule fluorescence microscopy to study replisome subunit dynamics in live yeast, showing long residence times and coordinated activity, redefining the replisome architecture.