Tania Auchynnikava

ESX-1 remodels the Mycobacterium tuberculosis antigen storage compartment in macrophages

The paper investigates how Mtb remodels antigen storage compartments in macrophages using a split fluorescent protein reporter and subcellular spatial proteomics.

Starvation improves epithelial fitness by selectively extruding DNA damaged cells

The paper shows that starvation-induced cell extrusion selectively removes DNA-damaged cells, improving tissue fitness through a p53-dependent pathway.

Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle

The paper shows phosphatase specificity affects CDK substrate phosphorylation timing during G2 and mitosis in fission yeast, establishing different phosphorylation thresholds at the G2/M transition.

A structural and regulatory framework for Atg9-containing vesicle formation and their Atg1-dependent remodelling during autophagy initiation

Control of CDK activity and the cell cycle by CKS proteins

This study identifies CKS proteins as multifaceted regulators of the cell cycle by modulating CDK activity and phosphorylation across diverse processes.

Identification of RING E3 pseudoligases in the TRIM protein family

The paper identifies RING E3 pseudoligases in the TRIM protein family by analyzing their structure and ubiquitin ligase activity, revealing structural divergence that impairs their function.

Meru co-ordinates spindle orientation with cell polarity and cell cycle progression

The paper shows Meru links spindle orientation with cell polarity and cell cycle progression in Drosophila SOPs by recruiting Mud and interacting with Cyclin A/Cdk1.

Dissecting PADI6 function defines oocyte cytoplasmic lattices as regulatory hubs for fundamental cellular processes

The paper investigates PADI6's role in oocyte cytoplasmic lattices using single-cell proteomics and transcriptomics, revealing its critical scaffolding function and connections to other oocyte compartments.