Author

Linda Helena Müller

Heidelberg UniversityORCID 0000-0002-9250-0541Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Brendan J. FloydiD· 2 shared Kai FenzliD· 2 shared Lars Michael SteinmetziD· 2 shared Victoria Nicole ParikhiD· 2 shared Adam S. HelmsiD· 1 shared Andrew David KrahniD· 1 shared Andrew Michael GlazeriD· 1 shared ANJALI TIKU OWENSiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Brendan J. FloydORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Damaging RBM20 E-rich domain variants are not rescued by gene replacement

Fang Bai, K.Y. Chua, Daniel Yuhang Li, Anna Kirillova, Sunil Yadav, David Staudt, Yuta Yamamoto, Hannah N. De Jong, Linda Helena Müller, Kai Fenzl, Non Rungaramsin, Yong Huang, Chloe M. Reuter, Steven Zhang, Vikki A. Krysov, , Victoria Nicole Parikh

The paper investigates E-rich domain variants of RBM20, showing they reduce protein abundance and cause splicing defects, but are not rescued by RBM20 overexpression.

bioRxiv · Jul 20, 2026 · PreprintGenetics

Multimodal phenotyping defines variant-to-function maps for RBM20 in dilated cardiomyopathy

Kai Fenzl, Linda Helena Müller, Julia Kornienko, Maria Majchrowska, Nils Eikmeier, Benjamin Wehnert, Edukondalu Mullapudi, Brendan J. Floyd, Brian Clarke, Kristian Schweimer, Janosch Hennig, Daniel Schraivogel, Victoria Nicole Parikh, Matthias Wilmanns, Lars Michael Steinmetz

The paper develops a deep mutational scanning framework to map variants to molecular functions in RBM20, identifying functional hotspots and therapeutic strategies for dilated cardiomyopathy.

bioRxiv · Jun 11, 2026 · PreprintGenomics