Anne Grünewald

This study investigates how SNCA triplication affects neuronal extracellular vesicle biology and microglial activation in Parkinson's disease using iPSC-derived models.

This study uses long-read sequencing to accurately detect low-frequency mitochondrial heteroplasmy in Parkinson's disease patients and carriers.

This study identifies ZFHX4 as a key regulator of midbrain dopaminergic neuron differentiation by controlling cell cycle progression through the LIN28A-miR-9 axis.

The paper uses single-nucleus RNA sequencing to identify cell type-specific dysregulation in Parkin-deficient neuron-microglia co-cultures, revealing distinct pathway disturbances in dopaminergic neurons and microglia.

The paper assesses mitochondrial DNA and neurofilament light chain levels in midbrain assembloids to identify Parkinson's disease phenotypes and potential biomarkers.

This study shows that a Miro1 mutation causes mitochondrial dysfunction and dopaminergic neuron loss in both cell models and mice, supporting its role in Parkinson's disease.

This study shows DJ-1 affects metabolism and immune response differently in Parkinson's disease and glioblastoma cells, with antioxidant treatment rescuing PD-related phenotypes.

The paper investigates DNA methylation and transcriptomic changes in chronic demyelinated MS lesions, showing hypermethylation of myelination-related genes and demonstrating reversible effects through epigenetic editing.

This study examines how a mitochondrial polygenic score interacts with environmental factors to influence age at onset in LRRK2-PD and iPD, finding ethnic-specific effects and gene-environment interactions.

The paper identifies mitochondrial DNA heteroplasmy as a marker distinguishing disease manifestation in PINK1/PRKN mutation carriers.

This study explores associations between coffee, smoking, and aspirin use with age at onset and clinical severity in idiopathic Parkinson's disease using a large cohort.

This study uses Nanopore sequencing to analyze mtDNA methylation in human blood samples, finding low-level methylation across the genome but noting challenges with Guppy calling affecting results.