Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses
Karina Lezgiyeva, Jingyi Liu, Karen Nguyen, Michelle M. DeLisle, Frank C. Ko, Spencer Fullam, Alia M. Obeidat, Josef Turecek, Ilayda Alkislar, Brendan P. Lehnert, Rosa I. Martinez-Garcia, Riya Sivakumar, Jinheon Choi, Ofer Mazor, Lilit Garibyan, , David D. Ginty
The paper identifies A{delta}-HTMRs as fast-conducting mechanonociceptors that drive protective pain responses through unique spinal reflex circuits.
Neuron · Jul 1, 2026Peer-reviewedNeuroscience