Lucas Prescott

Systematic Identification of Germ Granule Proteins Reveals Specialized Roles in RNAi and Small RNA Inheritance

The paper identifies new germ granule proteins in C. elegans and shows their roles in RNAi and small RNA inheritance, with PINT-1 being critical for siRNA biogenesis.

SARS-CoV-2 3CLpro Whole Human Proteome Cleavage Prediction and Enrichment/Depletion Analysis

The paper predicts SARS-CoV-2 3CLpro cleavage sites across the human proteome and identifies enriched/depleted tissues and pathways, proposing therapeutic targets.

Alphavirus nsP2 protease structure and cleavage prediction: Possible relevance to the pathogenesis of viral arthritis

The paper reveals novel molecular mechanisms of alphavirus nsP2 protease and predicts human proteins cleaved by these proteases, suggesting broader roles in viral arthritis pathogenesis.

SARS-CoV-2 PLpro whole human proteome cleavage prediction and enrichment/depletion analysis

The paper predicts human proteome cleavage sites by SARS-CoV-2 PLpro using neural networks and identifies novel potential therapeutic targets.