Author

Shihui Chen

University of Southern CaliforniaORCID 0009-0006-3036-5475Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein design· 1

Frequent Co-Authors

Carolyn Marie PhillipsiD· 3 shared Craig C. MelloiD· 1 shared Lucas PrescottiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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3 shared papersGenetics

Carolyn Marie PhillipsORCID

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3 papers

Recent·Most cited

GeneticsGenes & DevelopmentPeer-reviewedSep 1, 2026

Systematic Identification of Germ Granule Proteins Reveals Specialized Roles in RNAi and Small RNA Inheritance

Shihui Chen, Lucas Prescott, Craig C. Mello, Carolyn M. Phillips

The paper identifies new germ granule proteins in C. elegans and shows their roles in RNAi and small RNA inheritance, with PINT-1 being critical for siRNA biogenesis.

2 citations

C. elegansproteomics

𝕏 PostBluesky

Cell BiologyeLifePeer-reviewedOct 21, 2024

Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity

Shihui Chen, Carolyn Marie Phillips

The paper shows NRDE-3 switches small RNA partners during embryogenesis to regulate gene expression in somatic cells.

9 citations

C. elegansexperimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedFeb 1, 2024

Germ granule association drives small RNA specificity for a nuclear Argonaute protein

Shihui Chen, Carolyn M. Phillips

The paper shows that HRDE-2 mediates the localization of HRDE-1 to germ granules, which is essential for its specific binding to small RNAs and proper gene silencing in C. elegans.

20 citations

C. elegansproteomics

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